Anti-allergic and anti-inflammatory compounds from Aglaia andamanica leaves

The leaves from Aglaia andamanica were determined for their anti-allergic and anti-inflammatory effects using RBL2H3 and RAW264.7 cells, respectively. Among the isolated compounds, 24-epi-piscidinol A (5) exhibited the highest antiallergic activity against -hexosaminidase release with an IC50 value of 19.8 M, followed by (-)-yangambin (3, IC50 = 33.8 M), pyramidaglain A (8, IC50 = 37.1 M), pachypodol (2, IC50 = 38.3 M) and pyramidaglain B (9, IC50 = 44.8 M), respectively; whereas other compounds possessed moderate to mild effects (IC50 = 67.5->100 M). For anti-inflammatory activity, 24-epi-piscidinol A (5) possessed potent activity with an IC50 value of 24.0 M, followed by pyramidaglain B (9, IC50 = 25.6 M), pachypodol (2, IC50 = 34.5 M) and (-)-yangambin (3, IC50 = 37.4 M), respectively; whereas other compounds exhibited moderate to mild activities (IC50 = 54.2->100 M). These active compounds could be developed as anti-allergic and anti-inflammatory agents in the future.